Fodor I, Grabko V I, Khozinski V V, Selimov M A
Institute for Biochemistry and Protein Research, Agricultural Biotechnology Center, Gödöllö, Hungary.
Arch Virol. 1994;135(3-4):451-9. doi: 10.1007/BF01310030.
The glycoprotein gene of the rabies virus vaccine strain Vnukovo-32 was sequenced and the deduced protein sequence was analyzed and compared with that of various laboratory and street strains. The amino acid sequence homologies of strain Vnukovo-32 were compared with fixed strains ERA, SAD B19, PV, HEP-Flury, CVS and two street strains, canine and CXX89-1, were 98.9% (6 replacements), 98.3% (9), 96.2% (20), 91.4% (45), 87.0% (68), 93.5% (34) and 91.4% (45), respectively. Sequence alignments of the proteins revealed that the most conserved region is the ectodomain, whereas the transmembrane and cytoplasmic domains showed significant divergence.
对狂犬病病毒疫苗株Vnukovo - 32的糖蛋白基因进行了测序，并对推导的蛋白质序列进行了分析，并与各种实验室毒株和街毒株的序列进行了比较。将Vnukovo - 32株与固定毒株ERA、SAD B19、PV、HEP - Flury、CVS以及两种街毒株犬源毒株和CXX89 - 1的氨基酸序列同源性分别为98.9%（6个替换）、98.3%（9个）、96.2%（20个）、91.4%（45个）、87.0%（68个）、93.5%（34个）和91.4%（45个）。蛋白质序列比对显示，最保守的区域是胞外域，而跨膜域和胞质域则表现出显著差异。
