Jung H J, Fahey G C
J Nutr. 1983 Mar;113(3):546-56. doi: 10.1093/jn/113.3.546.
Phenolic monomers identified in common roughages were included in diets fed to rats both as mixtures, to mimic phenolic composition of roughages, and individually at various levels. Three performance and digestion/metabolism trials were conducted. Dry matter, protein, total carbohydrate, cellulose, and soluble carbohydrate (dextrose plus starch) digestibilities were measured. Urine and fecal samples were analyzed for phenolic monomers in trial 1. Inclusion of phenolic monomers (p-coumaric, ferulic, protocatechuic and salicylic acids, and vanillin) in rat diets resulted in reduced feed intake with a linear trend toward decreased intake with increasing dietary phenolic (p-coumaric and ferulic acids) concentrations. Average daily gain also exhibited a similar negative linear relationship. p-Coumaric and ferulic acids did not differ from one another in their effects, whereas salicylic acid had greater negative effects and vanillin was not different from the phenolic-free control. Some differences in digestibility of individual nutrients were observed, but were small in magnitude and did not correlate well with the altered growth responses. Analysis of urine and feces revealed low recoveries of phenolic monomers, suggesting extensive metabolism of phenolics by rats after intestinal absorption. Potential exists for phenolic monomers to be intake- and growth-depressing agents in both animal and human diets.
在常见粗饲料中鉴定出的酚类单体，以混合物形式（模拟粗饲料的酚类组成）和不同水平单独添加到大鼠饲料中。进行了三项生长性能和消化/代谢试验。测定了干物质、蛋白质、总碳水化合物、纤维素和可溶性碳水化合物（葡萄糖加淀粉）的消化率。在试验1中对尿液和粪便样本进行了酚类单体分析。在大鼠日粮中添加酚类单体（对香豆酸、阿魏酸、原儿茶酸、水杨酸和香草醛）导致采食量降低，随着日粮中酚类物质（对香豆酸和阿魏酸）浓度增加，采食量呈线性下降趋势。平均日增重也呈现出类似的负线性关系。对香豆酸和阿魏酸的影响没有差异，而水杨酸的负面影响更大，香草醛与不含酚类的对照组没有差异。观察到个别营养素消化率存在一些差异，但幅度较小，且与生长反应的改变相关性不佳。尿液和粪便分析显示酚类单体回收率较低，表明大鼠肠道吸收后酚类物质发生了广泛代谢。酚类单体在动物和人类日粮中都有可能成为抑制采食量和生长的物质。
