Prasad V K, Shah V P, Hunt J, Purich E, Knight P, Cabana B E
J Pharm Sci. 1983 Jan;72(1):42-4. doi: 10.1002/jps.2600720110.
Dissolution studies using both basket and paddle methods were carried out to evaluate two prednisone standards. Results of the experiments showed that the USP prednisone calibrator is sensitive to perturbations by the basket method but not to perturbations by the paddle method. However, the National Center for Drug Analysis (NCDA) prednisone performance standard is sensitive to perturbations by the paddle method but not to perturbations by the basket method. These results suggest that no single standard can predict the suitability of the dissolution equipment by the basket and paddle methods.
采用篮法和桨法进行溶出度研究，以评估两种泼尼松标准品。实验结果表明，美国药典泼尼松校准品对篮法的干扰敏感，但对桨法的干扰不敏感。然而，国家药物分析中心（NCDA）泼尼松性能标准品对桨法的干扰敏感，但对篮法的干扰不敏感。这些结果表明，没有单一的标准品能够通过篮法和桨法预测溶出设备的适用性。
