White D J, Christoffersen J, Herman T S, Lanzalaco A C, Nancollas G H
J Urol. 1983 Jan;129(1):175-9. doi: 10.1016/s0022-5347(17)51977-1.
Activated carbon and calcium oxalate solids have been used as adsorbents to remove crystallization inhibiting species from centrifuged and dialyzed normal urines. The urine supernatants, following adsorption treatments, have been examined for their calcium oxalate monohydrate crystallization inhibitory potentials by means of a constant composition potentiostatic seeded growth method. The supersaturation of the reactant solution was maintained constant during the crystallization process by the potentiometrically monitored addition of solutions containing crystal lattice ions controlled by a specific calcium ion selective electrode. The experimental results indicate that normal urine contains a number of inhibiting species of variable molecular weight and adsorbability. In addition, preliminary results indicate that substances present in normal urine interfere substantially with the adsorption of crystallization inhibiting species by calcium oxalate monohydrate crystal surfaces. Both charcoal and CaOx adsorbents have been successfully used to completely remove a synthetic, model urinary crystallization inhibitor, ethylene-diamine-tetramethylene-phosphonic acid, ENTMP, from relatively concentrated solutions in 0.15 M NaCl.
活性炭和草酸钙固体已被用作吸附剂，以从离心和透析后的正常尿液中去除结晶抑制物质。经过吸附处理后的尿液上清液，已通过恒组成恒电位晶种生长法检测其对一水合草酸钙结晶的抑制潜力。在结晶过程中，通过由特定钙离子选择性电极控制的含晶格离子溶液的电位监测添加，使反应物溶液的过饱和度保持恒定。实验结果表明，正常尿液含有多种分子量和吸附性各异的抑制物质。此外，初步结果表明，正常尿液中的物质会严重干扰一水合草酸钙晶体表面对结晶抑制物质的吸附。木炭和草酸钙吸附剂均已成功用于从0.15 M氯化钠的相对浓缩溶液中完全去除一种合成的模型尿结晶抑制剂，即乙二胺四亚甲基膦酸（ENTMP）。
