Tiselius H G, Fornander A M, Nilsson M A
Urol Res. 1987;15(2):83-6. doi: 10.1007/BF00260938.
Chromatographic separation of urine showed inhibition of calcium oxalate (CaOx)-crystallization among substances with both large and small molecular weights. Ultrafiltration showed that approximately 80 per cent of the inhibiting activity, as determined in 2 per cent urine, originated from substances with a molecular weight above 1,000. Dialysed urine was diluted to 7.5 mmol of creatinine per 1 and supersaturated with respect to CaOx. The rate of crystallization in these samples was slower in normal subjects than in stone formers (p less than 0.05). The inhibiting activity in diluted urine from the two groups did not differ and neither did the concentration of alcian blue precipitable polyanions. From measurements in diluted urine it was apparent that inhibition was demonstrable with a urine concentration as low as 0.3 per cent.
尿液的色谱分离显示，在大分子和小分子物质中均存在草酸钙（CaOx）结晶抑制现象。超滤结果表明，在2%的尿液中测定的约80%的抑制活性来自分子量高于1000的物质。将透析后的尿液稀释至每升含7.5 mmol肌酐，并使其相对于CaOx过饱和。这些样本中，正常受试者的结晶速率比结石形成者慢（p<0.05）。两组稀释尿液中的抑制活性没有差异，阿尔新蓝可沉淀聚阴离子的浓度也没有差异。从稀释尿液的测量结果来看，很明显，尿液浓度低至0.3%时仍可显示出抑制作用。
