Speit G
Mutat Res. 1983 Mar;119(3):371-6. doi: 10.1016/0165-7992(83)90187-2.
Maleic hydrazide (MH) in high concentrations (from 8 X 10(-3)M upward) induces SCEs in human blood cultures if it is added either for the entire culture period (72 h) or for the last 24 h. Parallel to the induction of SCEs, there is a delay in the proliferation of the cultures, as can be seen by the distribution of the first, second and third mitoses following the addition of BrdUrd. MH leads to a pronounced induction of SCEs in V79 cells (quadrupeling the control value) if added for 24 h simultaneously with BrdUrd. Treating the cells for 1 or 3 h prior to the addition of BrdUrd has no or little effect on the frequencies of SCEs.
高浓度（8×10⁻³M及以上）的马来酰肼（MH），若在整个培养期（72小时）或最后24小时添加到人体血培养物中，会诱导姐妹染色单体交换（SCEs）。与SCEs的诱导同时发生的是，培养物的增殖出现延迟，这可从添加溴脱氧尿苷（BrdUrd）后第一次、第二次和第三次有丝分裂的分布情况看出。若与BrdUrd同时添加24小时，MH会导致V79细胞中SCEs显著诱导（使对照值增加四倍）。在添加BrdUrd之前对细胞处理1小时或3小时，对SCEs频率没有影响或影响很小。
