Lane D M, McConathy W J
Pediatr Res. 1983 Feb;17(2):83-91. doi: 10.1203/00006450-198302000-00001.
In studying the human lipid transport system as it changes from the fetal to the adult form, data were collected on cord sera levels of lipids and apolipoproteins (A-I, A-II, ApoB, C-I, C-II, C-III, ApoD, and ApoE) from infants whose lipid metabolism might have been modified by a variety of factors present before, at, or after delivery. The results clearly indicated that many factors affect the levels of both lipids and apolipoproteins at birth. Method of delivery had little effect except in relation to either fetal immaturity (increased total cholesterol) or fetal stress (increased triglycerides). Birth weight was related to changes in free cholesterol, C-I, C-III, and ApoE levels. Gestational age had greater impact upon both serum lipids and apolipoproteins. With increasing fetal maturity, total cholesterol, free cholesterol, A-II, C-II, and ApoE progressively fell whereas triglyceride and ApoD rose. A variety of clinical disorders were also associated with changes in serum lipid and apolipoproteins. Anencephaly produced marked increases in both free and total cholesterol as well as most apolipoproteins. Significant reductions in triglyceride and ApoD levels were found in infants who subsequently became ill in the postnatal period with problems relating to carbohydrate metabolism (e.g., infants of diabetic mothers). Infants with respiratory distress were found to have decreased levels of total cholesterol and ApoB, both of which are increased in prematurity, a condition with which respiratory distress (RD) is usually associated. The changes in cord sera lipid and apolipoprotein levels found in a variety of clinical situations may provide new diagnostic approaches to postnatal problems arising in the newborn.
在研究人类脂质转运系统从胎儿形式转变为成人形式的过程中，收集了来自婴儿的脐带血清脂质和载脂蛋白（A-I、A-II、载脂蛋白B、C-I、C-II、C-III、载脂蛋白D和载脂蛋白E）水平的数据，这些婴儿的脂质代谢可能已被分娩前、分娩时或分娩后存在的多种因素所改变。结果清楚地表明，许多因素会影响出生时脂质和载脂蛋白的水平。分娩方式影响不大，除非与胎儿不成熟（总胆固醇升高）或胎儿应激（甘油三酯升高）有关。出生体重与游离胆固醇、C-I、C-III和载脂蛋白E水平的变化有关。胎龄对血清脂质和载脂蛋白的影响更大。随着胎儿成熟度的增加，总胆固醇、游离胆固醇、A-II、C-II和载脂蛋白E逐渐下降，而甘油三酯和载脂蛋白D则上升。多种临床疾病也与血清脂质和载脂蛋白的变化有关。无脑儿会导致游离胆固醇和总胆固醇以及大多数载脂蛋白显著升高。在出生后因碳水化合物代谢问题（如糖尿病母亲的婴儿）而患病的婴儿中，发现甘油三酯和载脂蛋白D水平显著降低。发现患有呼吸窘迫的婴儿总胆固醇和载脂蛋白B水平降低，而这两者在早产时会升高，呼吸窘迫（RD）通常与早产有关。在各种临床情况下发现的脐带血清脂质和载脂蛋白水平的变化可能为新生儿出生后出现的问题提供新的诊断方法。
