Tanimura A, McGregor D H, Anderson H C
Proc Soc Exp Biol Med. 1983 Feb;172(2):173-7. doi: 10.3181/00379727-172-41542.
Matrix vesicles, small extracellular membranous structures, are known to be the initial loci of calcification of cartilage, bone, and dentin. Calcification is an important complication of atherosclerosis. Using histologic, ultrastructural, and cytochemical techniques, the present study has demonstrated that matrix vesicle-like structures are involved in the calcification of atherosclerotic lesions, as well as in arterial medial calcification. In aortas from autopsied humans and from rabbits and chickens on atherogenic diets, the matrix vesicles appear to be derived from intimal and medial cellular components, mainly smooth muscle cells.
基质小泡是一种小的细胞外膜性结构，已知是软骨、骨和牙本质钙化的起始部位。钙化是动脉粥样硬化的一种重要并发症。本研究运用组织学、超微结构和细胞化学技术证明，基质小泡样结构参与动脉粥样硬化病变的钙化过程，也参与动脉中层钙化。在取自尸检人体以及喂食致动脉粥样化饮食的兔和鸡的主动脉中，基质小泡似乎源自内膜和中膜的细胞成分，主要是平滑肌细胞。
