Poling A, Kesselring J, Sewell R G, Cleary J
Pharmacol Biochem Behav. 1983 Jan;18(1):103-5. doi: 10.1016/0091-3057(83)90258-7.
Lethality of 80 mg/kg pentazocine alone; 40 mg/kg tripelennamine alone; 20 mg/kg tripelennamine in combination with 40, 60, and 80 mg/kg pentazocine; and 40 mg/kg tripelennamine in combination with 10, 20, and 40 mg/kg pentazocine was determined in mice housed individually and in groups. Results indicate that the lethality of pentazocine and tripelennamine combinations in mice is (1) dose-dependent, (2) potentiated relative to either drug alone, and (3) greater in group-housed than in individually-housed animals.
单独使用80毫克/千克喷他佐辛、单独使用40毫克/千克曲吡那敏、20毫克/千克曲吡那敏与40、60和80毫克/千克喷他佐辛联合使用、以及40毫克/千克曲吡那敏与10、20和40毫克/千克喷他佐辛联合使用时的致死率，在单独饲养和群居的小鼠中进行了测定。结果表明，喷他佐辛和曲吡那敏联合使用对小鼠的致死率具有以下特点：（1）剂量依赖性；（2）相对于单独使用任何一种药物均有增强作用；（3）在群居小鼠中比单独饲养的小鼠更高。
