Beatty W W, Rush J R
Pharmacol Biochem Behav. 1983 Jan;18(1):7-12. doi: 10.1016/0091-3057(83)90242-3.
To assess the possible involvement of the monoaminergic neurotransmitters norepinephrine, dopamine and serotonin in the maintenance of spatial working memory rats were treated with antagonists 0 or 2 hr after completing the first 4 choices in an 8 arm maze. Haloperidol (0.25-1 mg/kg), when administered 2 hr after Choice 4, produced a small but consistent impairment in performance on retention tests given 5 hr after the first 4 choices. This deficit closely resembled natural forgetting in terms of the type of errors committed. By contrast, haloperidol in the same doses given 0 hr after Choice 4 or 3 hr before the first 4 choices did not affect retention. Likewise treatment with propranolol (10-20 mg/kg), phentolamine (5-20 mg/kg) or methysergide (5-15 mg/kg) did not impair spatial memory, regardless of when these drugs were injected within the session. Evidently dopaminergic neuronal systems are important in the maintenance of normal spatial working memory.
为评估单胺能神经递质去甲肾上腺素、多巴胺和5-羟色胺在空间工作记忆维持中的可能作用，在8臂迷宫中大鼠完成前4次选择后0或2小时，用拮抗剂对其进行处理。在第4次选择后2小时给予氟哌啶醇（0.25 - 1毫克/千克），在第1次4次选择后5小时进行的记忆测试中，会产生轻微但持续的行为损伤。就所犯错误的类型而言，这种缺陷与自然遗忘非常相似。相比之下，在第4次选择后0小时或前4次选择前3小时给予相同剂量的氟哌啶醇并不影响记忆。同样，无论在实验过程中何时注射普萘洛尔（10 - 20毫克/千克）、酚妥拉明（5 - 20毫克/千克）或麦角酰二乙胺（5 - 15毫克/千克），均不会损害空间记忆。显然，多巴胺能神经元系统在正常空间工作记忆的维持中很重要。
