Kirschstein R L
Public Health Rep. 1983 Jan-Feb;98(1):40-3.
The National Institute of General Medical Sciences has as its mission the support of research and research training in the basic biomedical sciences. Grantees of the Institute have made major discoveries about cell structure and function, the synthesis and transport of body proteins, drug actions in the body, and the body's responses to severe trauma and burns. Advances in the field of genetics--including the development of recombinant DNA technology, in which Institute grantees have been leaders--are beginning to pay off in scientists' ability to understand the growth, differentiation, and development of cells, tissues, and organs; the regulation of gene activity; and the bases of certain genetic diseases. But while much has been learned, the cellular and molecular mechanisms of many illnesses are only beginning to be understood. For this reason, the Institute's support of studies of life processes at their most fundamental levels is expected to continue to produce findings of great importance to the understanding, prevention, and treatment of human disease.
美国国立综合医学科学研究所的使命是支持基础生物医学科学领域的研究和研究培训。该研究所的受资助者在细胞结构与功能、人体蛋白质的合成与运输、药物在体内的作用以及人体对严重创伤和烧伤的反应等方面取得了重大发现。遗传学领域的进展——包括重组DNA技术的发展，该研究所的受资助者在这方面一直处于领先地位——正开始在科学家理解细胞、组织和器官的生长、分化和发育、基因活性的调节以及某些遗传疾病的病因方面取得成效。尽管已经了解了很多，但许多疾病的细胞和分子机制才刚刚开始被理解。因此，该研究所对生命过程最基本层面研究的支持有望继续产生对人类疾病的理解、预防和治疗具有重要意义的发现。
