Gordon H W
Division of Epidemiology and Prevention Research, National Institute on Drug Abuse, Rockville, Maryland, USA.
Am J Med Genet. 1994 Dec 15;54(4):300-3. doi: 10.1002/ajmg.1320540404.
It is becoming clear that there is a genetic component to drug abuse. Family studies, adoption studies, and critical twin studies have all pointed to some genetic vulnerability or risk factors for an individual to abuse psychoactive drugs depending on certain psychopathologies in the biological parents and/or parents' own drug use. The question for the next generation of research at the National Institute on Drug Abuse (NIDA) is to apply the rapidly developing technology in molecular genetics in an effort to determine the candidate genes contributing to the risk.
越来越明显的是，药物滥用存在遗传因素。家族研究、收养研究和关键双胞胎研究均指出，个体滥用精神活性药物存在一些遗传易感性或风险因素，这取决于生物学父母的某些精神病理学特征和/或父母自身的药物使用情况。美国国立药物滥用研究所（NIDA）下一代研究的问题是应用分子遗传学中迅速发展的技术，以确定导致这种风险的候选基因。
