Pucci C, Poma S, Quarti Trevano G, Ferro C, Pizzocaro M, Ferri O
Radiol Med. 1983 Jan-Feb;69(1-2):7-10.
Barium peritonites are known to be a serious complication of barium enema examinations, being accompanied by a high mortality rate. The authors made their study injecting barium and radioactive 133Ba in the peritoneum of 68 rats without causing damages to the colon, in order to verify the toxicity of barium if injected in the peritoneum, and to evaluate the various extraperitoneal locations. Moreover, they compared the alterations caused by this agent with those consequent to a similar agent, such as talcum. The results show that barium is not toxic on its own: it gives in fact origin to granulomas similar to those caused by talcum; a particular tropism for the lymphatic tissues is present as well.
钡剂性腹膜炎是钡剂灌肠检查的一种严重并发症，死亡率很高。作者对68只大鼠的腹膜注射钡剂和放射性133Ba，且不损伤结肠，以验证钡剂注入腹膜后的毒性，并评估其在腹膜外的不同分布位置。此外，他们将这种药剂引起的改变与滑石粉等类似药剂引起的改变进行了比较。结果表明，钡剂本身并无毒性：事实上，它会引发与滑石粉引起的类似肉芽肿；对淋巴组织也有特殊的嗜性。
