Takahashi S, Patrick G
Radiat Res. 1987 Jun;110(3):321-8.
Long-term retention of 133Ba in the trachea from intratracheally administered BaSO4 particles was determined by both serial sacrifice and external scanning methods up to 6 months after injection. The amount of 133Ba retained 1 week after injection in the caudal region of the trachea, where the tip of the cannula had been at injection, was 0.41% of the initial dose. Thereafter the 133Ba was cleared exponentially with a mean half-time of 88 days, as determined from the autopsy samples. The cranial region of the trachea, including the site of the tracheostomy, contained 133Ba at 10 times the level in the caudal region 1 week after injection and was cleared with a half-time of 66 days. These clearance rates were confirmed by repeated external scanning over the trachea. The 133Ba was drained to the lymph nodes not only in the thoracic cavity but also in the cervical region, suggesting the possibility of lymphatic drainage from the trachea to the cervical lymph nodes.
通过连续处死和外部扫描方法，测定了气管内注射硫酸钡颗粒后133Ba在气管中的长期滞留情况，直至注射后6个月。注射1周后，插管尖端在注射时所在的气管尾部区域中保留的133Ba量为初始剂量的0.41%。此后，根据尸检样本确定，133Ba呈指数清除，平均半衰期为88天。气管的头部区域，包括气管造口部位，在注射1周后所含133Ba的水平是尾部区域的10倍，并以66天的半衰期清除。这些清除率通过对气管的反复外部扫描得到证实。133Ba不仅引流至胸腔内的淋巴结，还引流至颈部区域的淋巴结，提示气管向颈部淋巴结进行淋巴引流的可能性。
