• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

视紫红质漂白过程中中间体的傅里叶变换红外差谱。

Fourier transform infrared difference spectra of intermediates in rhodopsin bleaching.

作者信息

Rothschild K J, Cantore W A, Marrero H

出版信息

Science. 1983 Mar 18;219(4590):1333-5. doi: 10.1126/science.6828860.

DOI:10.1126/science.6828860
PMID:6828860
Abstract

The membrane protein rhodopsin is the primary light receptor in vision. Fourier transform infrared difference spectroscopy is sensitive to conformational changes in both the protein and the retinylidene chromophore of rhodopsin. By blocking rhodopsin bleaching at specific intermediates, it is possible to elucidate some of the primary molecular events of vision.

摘要

膜蛋白视紫红质是视觉中的主要光感受器。傅里叶变换红外差光谱对视紫红质的蛋白质和视黄醛发色团的构象变化都很敏感。通过在特定中间体处阻断视紫红质的漂白，可以阐明一些视觉的主要分子事件。

相似文献

1
Fourier transform infrared difference spectra of intermediates in rhodopsin bleaching.视紫红质漂白过程中中间体的傅里叶变换红外差谱。
Science. 1983 Mar 18;219(4590):1333-5. doi: 10.1126/science.6828860.
2
Fourier-transform infrared spectroscopy applied to rhodopsin. The problem of the protonation state of the retinylidene Schiff base re-investigated.傅里叶变换红外光谱法应用于视紫红质。视黄叉席夫碱质子化状态问题的重新研究。
Eur J Biochem. 1983 Oct 17;136(1):119-27. doi: 10.1111/j.1432-1033.1983.tb07714.x.
3
Fourier-transform infrared difference spectroscopy of rhodopsin and its photoproducts at low temperature.视紫红质及其光产物在低温下的傅里叶变换红外差光谱
Biochemistry. 1985 Oct 22;24(22):6055-71. doi: 10.1021/bi00343a006.
4
Fourier transform infrared study of photoreceptor membrane. I. Group assignments based on rhodopsin delipidation and reconstitution.光感受器膜的傅里叶变换红外光谱研究。I.基于视紫红质脱脂和重组的基团归属。
Biochim Biophys Acta. 1980 Mar 13;596(3):338-51. doi: 10.1016/0005-2736(80)90121-2.
5
Evidence for rhodopsin refolding during the decay of Meta II.在Meta II衰变过程中视紫红质重新折叠的证据。
Biophys J. 1987 Feb;51(2):345-50. doi: 10.1016/S0006-3495(87)83341-6.
6
A comparative study of the infrared difference spectra for octopus and bovine rhodopsins and their bathorhodopsin photointermediates.章鱼和牛视紫红质及其光视紫红质光中间体的红外差光谱比较研究。
Biochemistry. 1989 Apr 18;28(8):3366-73. doi: 10.1021/bi00434a036.
7
Carboxyl group involvement in the meta I and meta II stages in rhodopsin bleaching. A Fourier transform infrared spectroscopic study.羧基在视紫红质漂白过程中I型中间体和II型中间体阶段的作用。傅里叶变换红外光谱研究。
Biochim Biophys Acta. 1985 Aug 28;809(1):97-106. doi: 10.1016/0005-2728(85)90172-0.
8
Photoexcitation of rhodopsin: conformation changes in the chromophore, protein and associated lipids as determined by FTIR difference spectroscopy.
Photochem Photobiol. 1988 Oct;48(4):497-504. doi: 10.1111/j.1751-1097.1988.tb02852.x.
9
Primary events in dim light vision: a chemical and spectroscopic approach toward understanding protein/chromophore interactions in rhodopsin.暗光视觉中的主要事件：一种理解视紫红质中蛋白质/发色团相互作用的化学和光谱学方法。
Chem Rec. 2004;4(2):120-35. doi: 10.1002/tcr.20000.
10
A spectroscopic study of rhodopsin alpha-helix orientation.视紫红质α-螺旋取向的光谱研究。
Biophys J. 1980 Jul;31(1):53-64. doi: 10.1016/S0006-3495(80)85040-5.

引用本文的文献

1
Structural basis for the allosteric modulation of rhodopsin by nanobody binding to its extracellular domain.变构调节结合到其细胞外结构域的纳米体对 rhodopsin 的结构基础。
Nat Commun. 2023 Aug 25;14(1):5209. doi: 10.1038/s41467-023-40911-9.
2
My remembrances of H.G. Khorana: exploring the mechanism of bacteriorhodopsin with site-directed mutagenesis and FTIR difference spectroscopy.我对H.G. 科拉纳的回忆：利用定点诱变和傅里叶变换红外差光谱法探索细菌视紫红质的机制。
Biophys Rev. 2023 Feb 6;15(1):103-110. doi: 10.1007/s12551-023-01046-9. eCollection 2023 Feb.
3
Rhodopsins: An Excitingly Versatile Protein Species for Research, Development and Creative Engineering.
视紫红质：一种用于研究、开发和创新工程的极具通用性的蛋白质种类。
Front Chem. 2022 Jun 22;10:879609. doi: 10.3389/fchem.2022.879609. eCollection 2022.
4
Analog Retinal Redshifts Visible Absorption of QuasAr Transmembrane Voltage Sensors into Near-infrared.模拟视网膜红移将 QuasAr 跨膜电压传感器的可见吸收转化为近红外光。
Photochem Photobiol. 2020 Jan;96(1):55-66. doi: 10.1111/php.13169. Epub 2019 Nov 10.
5
Raman spectroscopy of a near infrared absorbing proteorhodopsin: Similarities to the bacteriorhodopsin O photointermediate.近红外吸收类视紫红质的拉曼光谱：与菌紫质 O 光中间态的相似性。
PLoS One. 2018 Dec 26;13(12):e0209506. doi: 10.1371/journal.pone.0209506. eCollection 2018.
6
Spectral Tuning Mechanism of Primate Blue-sensitive Visual Pigment Elucidated by FTIR Spectroscopy.运用傅里叶变换红外光谱技术阐明灵长类动物蓝光敏感视觉色素的光谱调谐机制。
Sci Rep. 2017 Jul 7;7(1):4904. doi: 10.1038/s41598-017-05177-4.
7
Structural Changes in an Anion Channelrhodopsin: Formation of the K and L Intermediates at 80 K.一种阴离子通道视紫红质的结构变化：80K 时 K 和 L 中间体的形成
Biochemistry. 2017 Apr 25;56(16):2197-2208. doi: 10.1021/acs.biochem.7b00002. Epub 2017 Apr 10.
8
Local peptide movement in the photoreaction intermediate of rhodopsin.视紫红质光反应中间体中的局部肽段移动。
Proc Natl Acad Sci U S A. 2006 Aug 22;103(34):12729-34. doi: 10.1073/pnas.0601765103. Epub 2006 Aug 14.
9
A homology-based model of the human 5-HT2A receptor derived from an in silico activated G-protein coupled receptor.一种基于同源性的人类5-羟色胺2A受体模型，该模型源自计算机模拟激活的G蛋白偶联受体。
J Comput Aided Mol Des. 2002 Jul;16(7):511-20. doi: 10.1023/a:1021275430021.
10
Photoactivation of rhodopsin causes an increased hydrogen-deuterium exchange of buried peptide groups.视紫红质的光激活导致埋藏肽基团的氢-氘交换增加。
Biophys J. 1998 Jan;74(1):192-8. doi: 10.1016/S0006-3495(98)77779-3.