Bailey C H, Chen M
Science. 1983 Apr 1;220(4592):91-3. doi: 10.1126/science.6828885.
The morphological basis of the persistent synaptic plasticity that underlies long-term habituation and sensitization of the gill withdrawal reflex in Aplysia californica was explored by examining the fine structure of sensory neuron presynaptic terminals (the critical site of plasticity for the short-term forms of both types of learning) in control animals and in animals whose behavior had been modified by training. The number, size, and vesicle complement of sensory neuron active zones were larger in animals showing long-term sensitization than in control animals and smaller in animals showing long-term habituation. These changes are likely to represent an anatomical substrate for the memory consolidation of these tasks.
通过检查对照动物以及行为因训练而改变的动物中感觉神经元突触前终末（这两种学习短期形式的关键可塑性位点）的精细结构，探究了加州海兔鳃收缩反射长期习惯化和敏感化背后持续性突触可塑性的形态学基础。表现出长期敏感化的动物中，感觉神经元活性区的数量、大小和囊泡含量比对照动物更大，而表现出长期习惯化的动物中则更小。这些变化可能代表了这些任务记忆巩固的解剖学基础。
