Imamura T, Gandy J, Fukuto T R, Talbot P
Toxicology. 1983 Jan;26(1):73-9. doi: 10.1016/0300-483x(83)90058-6.
Oral administration of O,O,S-trimethyl phosphorothioate (OOS), an impurity in technical malathion, caused morphological changes in the bronchiolar epithelium of rat lungs. OOS-treated rat lungs had fewer but larger Clara (non-ciliated) cells than lungs from control rats given either corn oil or purified malathion. Moreover, lactate dehydrogenase (LDH) activity in bronchopulmonary lavage fluid was significantly higher in OOS than in control rats. We interpret these data to mean that OOS, and/or its metabolite(s) causes a lesion in the lung. Because of the widespread agricultural use of technical malathion, future work should address the significance of our findings and the possible toxic effect of OOS on lung tissue.
技术级马拉硫磷中的杂质O,O,S-三甲基硫代磷酸酯（OOS）经口服后，导致大鼠肺细支气管上皮出现形态学变化。与给予玉米油或纯化马拉硫磷的对照大鼠的肺相比，经OOS处理的大鼠肺中克拉拉（无纤毛）细胞数量更少但体积更大。此外，OOS处理组大鼠支气管肺泡灌洗液中的乳酸脱氢酶（LDH）活性显著高于对照组大鼠。我们将这些数据解读为OOS及其代谢物会导致肺部损伤。鉴于技术级马拉硫磷在农业中的广泛使用，未来的研究应探讨我们研究结果的意义以及OOS对肺组织可能产生的毒性作用。
