四氯化碳对注射甲基汞后大鼠组织中汞积累的影响。
The effects of CCl4 on the accumulation of mercury in rat tissues after methylmercury injection.
作者信息
Sato M, Takizawa Y
出版信息
Toxicol Lett. 1983 Feb;15(2-3):245-9. doi: 10.1016/0378-4274(83)90223-0.
Rats were administered a dose of 10 mg of CH3HgCl/kg by single s.c. injection. They were subsequently treated with 0.5 ml of CCl4/kg by three i.p. injections at 48-h intervals. The treatment with CCl4 resulted in the rise of total mercury level in brain, although the increase of mercury level was transitory and the difference between with and without CCl4 treatment gradually diminished. In addition, the mercury levels in other tissues involving liver, kidney, and muscle were increased by the treatment with CCl4. These results suggest that a hepatic damage by CCl4 is responsible for the duration of mercury accumulation in brain and other tissues after the single injection of methylmercury.
给大鼠单次皮下注射10毫克/千克的氯化甲基汞。随后，以每千克0.5毫升的四氯化碳，每隔48小时进行三次腹腔注射对其进行治疗。四氯化碳治疗导致大脑中总汞水平升高，尽管汞水平的升高是暂时的，且有无四氯化碳治疗之间的差异逐渐减小。此外，四氯化碳治疗使肝脏、肾脏和肌肉等其他组织中的汞水平升高。这些结果表明，四氯化碳造成的肝损伤是单次注射甲基汞后大脑和其他组织中汞积累持续时间的原因。
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