Burtsev E M, Usov L A, Atamaniuk E D, Miller L G
Zh Nevropatol Psikhiatr Im S S Korsakova. 1983;83(1):59-66.
Curantil intracarotid injection resulted in brain blood supply and in brain oxygen consumption increase as well as in redox processes normalization in 75 cats with main brain arteries occlusion and heart insufficiency induced by chemical necrosis of the myocardium. A single intravenous injection of a higher curantil dose resulted in a significantly less effect. Long-term (3-72 hours) curantil infusion led to the improvement of the functions disturbed (limb movements, speech, vision) in 32 of 42 patients with brain ischemic insult. The greatest therapeutic efficacy was observed in patients with nonobturated brain infarction induced by brain vascular spasm or cardiocerebral vascular insufficiency.
对75只因心肌化学性坏死导致大脑主要动脉闭塞和心脏功能不全的猫进行颈内动脉注射库拉替尔，结果显示脑供血、脑氧消耗增加，氧化还原过程恢复正常。单次静脉注射较高剂量的库拉替尔，效果明显较差。对42例脑缺血性损伤患者进行3至72小时的库拉替尔长期输注，结果显示其中32例患者的功能障碍（肢体运动、言语、视力）得到改善。在因脑血管痉挛或心脑血管功能不全导致的非闭塞性脑梗死患者中观察到最大的治疗效果。
