Plotnikov M B, Saratikov A S
Farmakol Toksikol. 1984 May-Jun;47(3):50-5.
In cats with intracerebral hemorrhage, prolonged intracarotid infusion of euphylline led to unfavourable changes in brain blood supply and metabolism. An increase in the overall cerebral circulation seen during infusion was replaced by a long-term lowering after its completion. Activation of brain oxygen consumption in the presence of the decreased cerebral circulation led to dysproportion between oxygen supply and consumption enhancing cerebral tissue hypoxia. Euphylline-induced glucose consumption with predominance of glucose anaerobic metabolism over aerobic one was followed by lactate accumulation in the brain. Taking into consideration the data obtained it is necessary to be very cautious as regards the use of intracarotid euphylline infusions in patients with subarachnoidal and intracerebral hemorrhages.
在患有脑出血的猫中，长时间颈内动脉输注氨茶碱会导致脑供血和代谢出现不良变化。输注期间观察到的脑循环总体增加在输注结束后被长期降低所取代。在脑循环减少的情况下脑氧消耗的激活导致氧供应与消耗之间的失衡，加剧了脑组织缺氧。氨茶碱诱导的葡萄糖消耗以无氧代谢为主，超过有氧代谢，随后大脑中乳酸积累。考虑到所获得的数据，在蛛网膜下腔出血和脑出血患者中使用颈内动脉氨茶碱输注时必须非常谨慎。
