Christensen C C, Frey H M, Foenstelien E, Aadland E, Refsum H E
Am J Clin Nutr. 1983 Mar;37(3):468-72. doi: 10.1093/ajcn/37.3.468.
To test the applicability of indirect estimation of daily energy expenditure from average daily heart rate (HR) and individual O2-intake/heart rate (VO2/HR) regression lines in subjects with metabolic disorders, VO2/HR regression lines were determined on 2 consecutive days in 17 subjects (five healthy, five with obesity, five with untreated thyrotoxicosis, two with anorexia nervosa). Daily energy expenditure was calculated by means of the average 24 h HR. Generally, there was a high correlation coefficient for the relationship between VO2 and HR, but the slopes and intercepts varied considerably from day to day, leading to poor agreement between duplicate estimates of energy expenditures, and not infrequently to physiologically meaningless values. Further studies, comprising determination of the VO2/HR regression lines in three different body positions on 7 different days in one experienced test subject showed great variability of the VO2/HR regression lines, both in the same position and in different positions. The applied procedure seems unsuitable for metabolic studies in individual patients who engage in ordinary daily activities with low energy expenditure.
为了测试通过平均每日心率（HR）和个体氧摄取/心率（VO2/HR）回归线间接估计代谢紊乱患者每日能量消耗的适用性，对17名受试者（5名健康者、5名肥胖者、5名未经治疗的甲状腺毒症患者、2名神经性厌食症患者）连续两天测定VO2/HR回归线。通过平均24小时心率计算每日能量消耗。一般来说，VO2与HR之间的关系具有较高的相关系数，但斜率和截距每天变化很大，导致能量消耗重复估计值之间的一致性较差，且常常得出无生理意义的值。进一步的研究，包括在一名经验丰富的测试对象身上，于7个不同日期在三种不同体位测定VO2/HR回归线，结果显示VO2/HR回归线在相同体位和不同体位均有很大变异性。所应用的方法似乎不适用于从事低能量消耗日常活动的个体患者的代谢研究。
