Seike H, Takeuchi M, Kitamura Y, Sato B, Yamaguchi K, Matsumoto K
Anticancer Res. 1983 Jan-Feb;3(1):35-9.
An androgen-independent spindle-shaped cell tumor (NHD) formed from androgen-dependent medullary Shionogi carcinoma (SC115) in DS mice was examined. Although NHD tumors transplanted in female or male mice exhibited almost the same growth speed, the cytosol of this tumor was found to contain an androgen receptor which was similar in binding characteristics to SC115 tumor. Although significant amounts of specific binding sites for testosterone and 5 alpha-dihydrotestosterone were found in the SC115 nuclei as well as in the NHD nuclei shortly after the injection of 3H-testosterone, the androgens in the NHD nuclei disappeared rapidly. The androgen-independency of this tumor may be attributed to a rapid dissociation of the androgen-receptor complexes from NHD nuclei.
对源自DS小鼠雄激素依赖性髓质癌（SC115）形成的雄激素非依赖性梭形细胞瘤（NHD）进行了研究。尽管移植到雌性或雄性小鼠体内的NHD肿瘤生长速度几乎相同，但发现该肿瘤的细胞质中含有一种雄激素受体，其结合特性与SC115肿瘤相似。在注射3H-睾酮后不久，在SC115细胞核以及NHD细胞核中均发现了大量睾酮和5α-二氢睾酮的特异性结合位点，但NHD细胞核中的雄激素迅速消失。该肿瘤的雄激素非依赖性可能归因于雄激素受体复合物与NHD细胞核的快速解离。
