Kitamura Y, Uchida N, Hayata I, Yamaguchi K, Okamoto S, Narita N, Matsumoto K
Cancer Res. 1980 Dec;40(12):4781-5.
When Shionogi carcinoma 115 (SC115, an undifferentiated medullary carcinoma showing a compact cell pattern and containing androgen receptor) was transplanted into male and female DS mice, it grew only in males. In contrast with this strict androgen dependency in DS hosts, SC115 tumors grew in male and female nude athymic (BALB/c-nu/nu) mice. Although most of the tumors developing in female nude mice were composed of spindle-shaped cells and did not contain androgen receptor, about 5% of tumors in female nude mice retained morphological and biochemical characteristics of the original SC115 tumor. Such a tumor was serially transplanted in female nude mice. Although no significant changes were detectable in histological and chromosomal features and in androgen receptor values, the growth speed in female nude mice accelerated and became comparable to the growth speed of the original SC115 tumor in intact male DS mice. However, this subline of SC115 tumor showed a marked androgen dependency when reinoculated into male and female DS mice after 14 passages in female mice nude mice in spite of its relative androgen independency in nude hosts. Therefore, the present results seem to suggest that the immunological status of the hosts may affect the hormone dependency of tumors.
当将静冈癌115（SC115，一种未分化的髓样癌，呈致密细胞模式并含有雄激素受体）移植到雄性和雌性DS小鼠体内时，它仅在雄性小鼠中生长。与DS宿主中这种严格的雄激素依赖性相反，SC115肿瘤在雄性和雌性裸胸腺（BALB/c-nu/nu）小鼠中生长。尽管雌性裸鼠中发生的大多数肿瘤由梭形细胞组成且不含雄激素受体，但雌性裸鼠中约5%的肿瘤保留了原始SC115肿瘤的形态和生化特征。这样的肿瘤在雌性裸鼠中连续传代移植。尽管在组织学和染色体特征以及雄激素受体值方面未检测到明显变化，但雌性裸鼠中的生长速度加快，变得与完整雄性DS小鼠中原始SC115肿瘤的生长速度相当。然而，尽管SC115肿瘤的这个亚系在裸鼠宿主中相对雄激素不依赖，但在雌性裸鼠中传代14次后重新接种到雄性和雌性DS小鼠中时，它表现出明显的雄激素依赖性。因此，目前的结果似乎表明宿主的免疫状态可能会影响肿瘤的激素依赖性。
