Howe J G, Penney M D, Currie S, Morgan D
Ann Neurol. 1983 Feb;13(2):201-4. doi: 10.1002/ana.410130217.
A young man developed pathological thirst and hyperdipsia, hyperphagia, disordered temperature regulation, a lowered threshold for aggressive behavior, apathy, impaired memory, and seizures following encephalitis. He had marked hyponatremia. Bouts of water drinking produced water intoxication and precipitated status epilepticus. Studies of water handling with measurements of plasma osmolality and arginine vasopressin (AVP) revealed a very low thirst threshold (below 242 mOsm/kg) with resetting of the osmostat to a new level (255 mOsm/kg) but normal control of plasma osmolality at that level with adequate AVP release.
一名年轻男子在患脑炎后出现病理性口渴、饮水过多、食欲亢进、体温调节紊乱、攻击行为阈值降低、冷漠、记忆力减退和癫痫发作。他有明显的低钠血症。饮水发作导致水中毒并引发癫痫持续状态。通过测量血浆渗透压和精氨酸加压素（AVP）来研究水代谢，结果显示其口渴阈值极低（低于242毫渗摩尔/千克），渗透压调定点重置到一个新水平（255毫渗摩尔/千克），但在该水平下血浆渗透压通过足够的AVP释放得到正常调节。
