洛哌丁胺治疗严重迁延性腹泻
Loperamide in severe protracted diarrhoea.
作者信息
Sandhu B K, Tripp J H, Milla P J, Harries J T
出版信息
Arch Dis Child. 1983 Jan;58(1):39-43. doi: 10.1136/adc.58.1.39.
Abstract
Six infants with severe life-threatening protracted diarrhoea were treated with loperamide. Steady-state perfusion studies of the jejunum showed that in 2 of them the small intestine was in a net secretory state with respect to water, and in the others this was inferred from the fact that the diarrhoea persisted despite nothing by mouth. Loperamide resulted in a prompt and impressive improvement in the condition of each infant. We conclude that this drug has an important role in the management of protracted diarrhoeal states in some infants who are unresponsive to current treatments, and that its effect is related to its antisecretory action.
摘要
六名患有严重危及生命的持续性腹泻的婴儿接受了洛哌丁胺治疗。空肠的稳态灌注研究表明，其中两名婴儿的小肠处于水的净分泌状态，而其他婴儿则是根据尽管禁食但腹泻仍持续这一事实推断出处于这种状态。洛哌丁胺使每名婴儿的病情迅速且显著改善。我们得出结论，这种药物在治疗某些对当前治疗无反应的婴儿持续性腹泻状态中具有重要作用，并且其作用与其抗分泌作用有关。
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本文引用的文献
1
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Arch Dis Child. 1981 Jan;56(1):15-23. doi: 10.1136/adc.56.1.15.
2
Na+-dependent co-transport of alpha-methyl D-glucoside across the mucosal border of rabbit descending colon.α-甲基-D-葡萄糖苷通过兔降结肠黏膜边界的钠依赖性协同转运。
Biochim Biophys Acta. 1981 Jun 22;644(2):316-22. doi: 10.1016/0005-2736(81)90389-8.
3
Loperamide: studies on its mechanism of action.洛哌丁胺：其作用机制的研究
Gut. 1981 Aug;22(8):658-62. doi: 10.1136/gut.22.8.658.
4
Influence of opiates on ion transport across rabbit ileal mucosa.阿片类药物对兔回肠黏膜离子转运的影响。
Gastroenterology. 1981 Feb;80(2):279-84.
5
Effect of D-alanine methionine enkephalin amide on ion transport in rabbit ileum.D-丙氨酸甲硫氨酸脑啡肽酰胺对兔回肠离子转运的影响。
J Clin Invest. 1980 Jul;66(1):19-28. doi: 10.1172/JCI109830.
6
Speculations on the pathogenesis of diarrhea.关于腹泻发病机制的推测。
Fed Proc. 1967 Sep;26(5):1405-14.
7
Intractable diarrhea in early infancy.婴儿早期难治性腹泻
Pediatrics. 1968 Apr;41(4):712-22.
8
9
Loperamide in the symptomatic control of chronic diarrhoea. Double-blind placebo-controlled study.洛哌丁胺用于慢性腹泻的症状控制。双盲安慰剂对照研究。
Ann Clin Res. 1975 Oct;7(5):325-30.
10
[Effects of loperamide on the motility of the isolated intestine in guinea pigs, rats and dogs (author's transl)].
Nihon Heikatsukin Gakkai Zasshi. 1977 Jun;13(2):69-74. doi: 10.1540/jsmr1965.13.69.
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