洛哌丁胺治疗严重迁延性腹泻
Loperamide in severe protracted diarrhoea.
作者信息
Sandhu B K, Tripp J H, Milla P J, Harries J T
出版信息
Arch Dis Child. 1983 Jan;58(1):39-43. doi: 10.1136/adc.58.1.39.
Abstract
Six infants with severe life-threatening protracted diarrhoea were treated with loperamide. Steady-state perfusion studies of the jejunum showed that in 2 of them the small intestine was in a net secretory state with respect to water, and in the others this was inferred from the fact that the diarrhoea persisted despite nothing by mouth. Loperamide resulted in a prompt and impressive improvement in the condition of each infant. We conclude that this drug has an important role in the management of protracted diarrhoeal states in some infants who are unresponsive to current treatments, and that its effect is related to its antisecretory action.
摘要
六名患有严重危及生命的持续性腹泻的婴儿接受了洛哌丁胺治疗。空肠的稳态灌注研究表明，其中两名婴儿的小肠处于水的净分泌状态，而其他婴儿则是根据尽管禁食但腹泻仍持续这一事实推断出处于这种状态。洛哌丁胺使每名婴儿的病情迅速且显著改善。我们得出结论，这种药物在治疗某些对当前治疗无反应的婴儿持续性腹泻状态中具有重要作用，并且其作用与其抗分泌作用有关。
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