孕酮和他莫昔芬对雌二醇影响胎儿豚鼠子宫细胞核组蛋白乙酰化的快速调节作用。

Rapid modulation by progesterone and tamoxifen of estradiol effects on nuclear histone acetylation in the uterus of the fetal guinea pig.

作者信息

Pasqualini J R, Cosquer-Clavreul C, Gelly C

出版信息

Biochim Biophys Acta. 1983 Jan 20;739(1):137-40. doi: 10.1016/0167-4781(83)90054-4.

Abstract

The effect of estradiol, progesterone, tamoxifen, estradiol + progesterone or estradiol + tamoxifen on the [3H]acetylation of histones in the fetal uterus of guinea pig was studied. The fetuses were injected subcutaneously 'in situ' with the hormones or tamoxifen + [3H]acetate alone. In 10 min, estradiol stimulated the acetylation of histone 10-12-times with respect to the control animals. Progesterone and tamoxifen blocked this effect. It is suggested that histone acetylation is an early step induced by estrogen action during intrauterine life and that progesterone and tamoxifen suppress this mechanism very effectively.

摘要

研究了雌二醇、孕酮、他莫昔芬、雌二醇 + 孕酮或雌二醇 + 他莫昔芬对豚鼠胎儿子宫组蛋白[3H]乙酰化的影响。将胎儿“原位”皮下注射激素或单独注射他莫昔芬 + [3H]醋酸盐。10分钟内，相对于对照动物，雌二醇刺激组蛋白乙酰化10 - 12倍。孕酮和他莫昔芬阻断了这种作用。提示组蛋白乙酰化是子宫内生活期间雌激素作用诱导的早期步骤，且孕酮和他莫昔芬能非常有效地抑制这一机制。