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[与肿瘤细胞接触后自然杀伤细胞膜的可逆性损伤]

[Reversible injuries of the natural killer cell membrane after contact with tumor cells].

作者信息

Van'ko L V, Bogdashin I V, Fuks B B

出版信息

Biull Eksp Biol Med. 1983 Jan;95(1):82-4.

PMID:6830968
Abstract

Injuries to the normal killer membrane were studied during contact with tumor cells on isolated tumor cell-lymphocyte conjugates. The properties of the lymphocyte membrane were shown to undergo changes in the area of contact with the tumor cell membrane, manifesting in the increased membrane permeability for ribonuclease molecules. This effect was more pronounced if lymphocytes were used, in which the synthesis of RNA was suppressed.

摘要

在分离的肿瘤细胞 - 淋巴细胞结合物上,研究了正常杀伤细胞膜与肿瘤细胞接触时的损伤情况。结果显示,淋巴细胞膜的特性在与肿瘤细胞膜接触的区域发生了变化,表现为核糖核酸酶分子的膜通透性增加。如果使用RNA合成受到抑制的淋巴细胞,这种效应会更加明显。

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