Meerson F Z, Evsev'eva M E
Arkh Patol. 1983;45(5):26-32.
Rats with hemolytic (phenylhydrazine) anemia were shown to develop simultaneously with hypertrophy of the myocardium marked damages of cardiomyocytes of the type of I-III degree contractures, myocytolysis, vacuolation, fatty infiltration, small focal necrosis as well as a peculiar form of damages defined as "central lumpy degeneration". An inhibitor of lipid peroxidation, antioxidant ionol, decreases the extent of myocardial hypertrophy and the intensity of the above morphological changes in cardiomyocytes. This indicates a significant role of lipid peroxidation in myocardial damage in hemolytic anemia and the importance of research on the use of antioxidants in combined treatment of cardial disorders in patients with anemia.
实验表明，患有溶血性（苯肼）贫血的大鼠在心肌肥大的同时，会出现程度为I - III级的收缩性损伤、肌细胞溶解、空泡化、脂肪浸润、小灶性坏死等明显的心肌细胞损伤，以及一种特殊形式的损伤，即“中央块状变性”。脂质过氧化抑制剂抗氧化剂离子醇可降低心肌肥大的程度以及上述心肌细胞形态变化的强度。这表明脂质过氧化在溶血性贫血心肌损伤中起重要作用，同时也凸显了研究抗氧化剂在贫血患者心脏疾病联合治疗中应用的重要性。
