Cangir A, van Eys J, Berry D H, Hvizdala E, Morgan S K
Med Pediatr Oncol. 1978;4(3):253-61. doi: 10.1002/mpo.2950040309.
Twenty-three children with CNS tumors were treated with combination chemotherapy including nitrogen mustard, vincristine sulfate, procarbazine, and prednisone (MOPP). All but one had progressive or recurrent tumors following surgery and irradiation. In addition, nine of these patients had prior chemotherapy. Seventeen out of 23 patients (73.4%) responded to MOPP chemotherapy including seven patients who had prior chemotherapy with single or multiple agents such as VCR, nitrosoureas, intrathecal methotrexate, and VM-26. Three comatose patients who were being kept on Decadron without benefit recovered from coma. At the time of this report 8 of the 17 responders are surviving without evidence of recurrence 7--30 months from the start of MOPP chemotherapy. In two of these children chemotherapy has been completely stopped.
23名患有中枢神经系统肿瘤的儿童接受了联合化疗，化疗药物包括氮芥、硫酸长春新碱、丙卡巴肼和泼尼松（MOPP方案）。除1名患者外，其余患者在手术和放疗后均出现肿瘤进展或复发。此外，这些患者中有9名曾接受过化疗。23名患者中有17名（73.4%）对MOPP化疗有反应，其中包括7名曾接受过如长春新碱、亚硝基脲、鞘内注射甲氨蝶呤和威猛（VM-26）等单药或多药化疗的患者。3名一直使用地塞米松但无效的昏迷患者从昏迷中苏醒。在本报告发布时，17名有反应的患者中有8名在开始MOPP化疗后7至30个月存活，且无复发迹象。在其中两名儿童中，化疗已完全停止。
