Wolf H, Højgaard K
Cancer. 1983 May 1;51(9):1710-5. doi: 10.1002/1097-0142(19830501)51:9<1710::aid-cncr2820510925>3.0.co;2-n.
Thirty-three patients with bladder cancer of categories pT1 or pT2 were treated by transurethral resection alone. At the initial diagnosis random preselected site mucosal biopsies were obtained to demonstrate the presence or absence of concomitant urothelial dysplasia. A statistically significant (P less than 0.01) relationship was found between the presence or absence of concomitant urothelial dysplasia and the development of new occurrence or the absence of recurrence at cystoscopic follow-up. Four of six patients with concomitant carcinoma in situ developed invasive bladder cancer within 6 months demonstrating the serious prognostic significance of this entity. Thus, the presence or absence of concomitant urothelial dysplasia at the initial diagnosis of invasive bladder cancer seems to be an important prognostic factor for future new occurrences.
33例pT1或pT2期膀胱癌患者仅接受了经尿道切除术。在初次诊断时，随机选取预先选定部位的黏膜活检样本，以证明是否存在伴发的尿路上皮发育异常。在膀胱镜随访中，伴发的尿路上皮发育异常的存在与否与新发病例的发生或复发的有无之间存在统计学显著差异（P小于0.01）。6例伴有原位癌的患者中有4例在6个月内发展为浸润性膀胱癌，表明该实体具有严重的预后意义。因此，浸润性膀胱癌初次诊断时伴发的尿路上皮发育异常的存在与否似乎是未来新发病例的一个重要预后因素。
