Danes B S, Lynch H T
Cancer Genet Cytogenet. 1983 Jan;8(1):81-7. doi: 10.1016/0165-4608(83)90067-5.
Increased in vitro tetraploidy has been considered an in vitro expression of some cancer-prone genes in dermal monolayer cultures. (Danes BS, Alm T, Scand J Gastroenterol 16, 421-427, 1981; Danes BS, Cancer 48, 1596-1601, 1981). Its occurrence was determined in cultures established from skin biopsies from 112 normals (university students and personnel) whose family cancer histories were known to ascertain its relevance to cancer occurrence based on pedigree data. Of the 40 who gave no family cancer history, one showed increased in vitro tetraploidy (1% of the total studied; 2.5% of those without a family cancer history). Of the 72 with one or more first- or second-degree relatives with a family cancer history, 14 showed this alteration (12.5% of the total studied; 19% of those with a family cancer history). Increased in vitro tetraploidy was found in some normals from families with lung, breast, genital system, and gastrointestinal tract cancers. It may prove ultimately to be relevant to include such in vitro information in medical surveillance and cancer management programs.
体外四倍体增加被认为是皮肤单层培养中某些易患癌基因的体外表达。（丹麦人BS，阿尔姆T，《斯堪的纳维亚胃肠病学杂志》16，421 - 427，1981年；丹麦人BS，《癌症》48，1596 - 1601，1981年）。在从112名正常人（大学生和工作人员）的皮肤活检组织建立的培养物中确定了其发生情况，这些人的家族癌症病史已知，以便根据系谱数据确定其与癌症发生的相关性。在40名没有家族癌症病史的人中，有1人显示体外四倍体增加（占研究总数的1%；占无家族癌症病史者的2.5%）。在72名有一个或多个一级或二级亲属有家族癌症病史的人中，有14人显示出这种改变（占研究总数的12.5%；占有家族癌症病史者的19%）。在一些有肺癌、乳腺癌、生殖系统癌和胃肠道癌家族史的正常人中发现了体外四倍体增加。最终可能证明将此类体外信息纳入医学监测和癌症管理计划是相关的。
