桔霉素对雄性F344大鼠的致瘤性。
Tumorigenicity of citrinin in male F344 rats.
作者信息
Arai M, Hibino T
出版信息
Cancer Lett. 1983 Jan;17(3):281-7. doi: 10.1016/0304-3835(83)90165-9.
PMID:6831385
Abstract
This study reports on the tumorigenicity of citrinin, a nephrotoxic mycotoxin. Male F344 rats were fed 0.1% citrinin in the diet for up to 80 weeks. The first renal tumor was seen grossly in a rat receiving citrinin which was killed at week 52. Histopathology of the kidneys showed renal adenomas in 35 of 48 (72.9%) rats that survived after 40 weeks. No renal tumors were seen in the control rats.
摘要
本研究报告了肾毒性霉菌毒素桔青霉素的致瘤性。将0.1%的桔青霉素添加到雄性F344大鼠的饮食中，持续喂养长达80周。在第52周处死的一只接受桔青霉素喂养的大鼠中，肉眼首次观察到肾脏肿瘤。对40周后存活的48只大鼠中的35只（72.9%）进行肾脏组织病理学检查，发现有肾腺瘤。在对照大鼠中未观察到肾脏肿瘤。
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