Kessel D, Chou T H
Cancer Res. 1983 May;43(5):1994-9.
Synthetic and analytical approaches were used to characterize the tumor-localizing components of the porphyrin preparation, hematoporphyrin derivative. From studies involving aqueous and nonaqueous gel exclusion and reverse-phase chromatography, we conclude that localization is mediated by hematoporphyrin derivative components which are among the most hydrophobic in the preparation. This apparent hydrophobicity may derive from hydrogen-bonding phenomena, rather than from absence of hydrophilic functional groups.
采用合成和分析方法对卟啉制剂血卟啉衍生物的肿瘤定位成分进行了表征。通过涉及水性和非水性凝胶排阻及反相色谱的研究，我们得出结论，定位是由血卟啉衍生物成分介导的，这些成分是制剂中疏水性最强的成分之一。这种明显的疏水性可能源于氢键现象，而非缺乏亲水性官能团。
