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植物血凝素刺激的淋巴细胞中非组蛋白染色体蛋白的变化

Changes in nonhistone chromosomal proteins in phytohemagglutininstimulated lymphocytes.

作者信息

Blüthmann H

出版信息

Mol Biol Rep. 1978 Jun 16;4(2):97-100. doi: 10.1007/BF00775968.

DOI:10.1007/BF00775968
PMID:683187
Abstract

Stimulation of bovine lymphocytes with phytohemagglutinin results in quantitative as well as qualitative changes in the nonhistone chromosomal proteins. Analysis of these proteins by hydroxyapatite chromatography and sodium dodecylsulfate polyacrylamide gel electrophoresis shows not only a selective increase in the amount of some nonhistone proteins but also a decrease of other nonhistone protein bands. This observation is compatible with the view that nonhistone proteins have an inhibitory as well as an activating function at the genome level.

摘要

用植物血凝素刺激牛淋巴细胞会导致非组蛋白染色体蛋白在数量和质量上发生变化。通过羟基磷灰石色谱法和十二烷基硫酸钠聚丙烯酰胺凝胶电泳对这些蛋白质进行分析，结果表明，不仅某些非组蛋白的量有选择性增加，而且其他非组蛋白蛋白条带减少。这一观察结果与非组蛋白在基因组水平上具有抑制和激活功能的观点相符。

相似文献

1
Changes in nonhistone chromosomal proteins in phytohemagglutininstimulated lymphocytes.植物血凝素刺激的淋巴细胞中非组蛋白染色体蛋白的变化
Mol Biol Rep. 1978 Jun 16;4(2):97-100. doi: 10.1007/BF00775968.
2
Specific binding of a nonhistone chromosomal protein from lymphocyte to DNA.
Eur J Biochem. 1976 Nov 1;70(1):233-40. doi: 10.1111/j.1432-1033.1976.tb10974.x.
3
Selective stimulation of nonhistone chromatin protein synthesis in lymphoid cells by phytohemagglutinin.植物血凝素对淋巴细胞中非组蛋白染色质蛋白合成的选择性刺激作用。
Biochemistry. 1973 Jan 16;12(2):224-8. doi: 10.1021/bi00726a008.
4
Molecular events in lymphocyte differentiation: stimulation of nonhistone nuclear protein synthesis in rabbit peripheral blood lymphocytes by anti-immunoglobulin.淋巴细胞分化中的分子事件：抗免疫球蛋白对兔外周血淋巴细胞非组蛋白核蛋白合成的刺激作用
Biochem Biophys Res Commun. 1977 Jan 24;74(2):584-91. doi: 10.1016/0006-291x(77)90343-6.
5
DNA-binding properties of a nonhistone chromosomal protein from lymphocytes.淋巴细胞中非组蛋白染色体蛋白的DNA结合特性
Mol Cell Biochem. 1978 May 31;19(3):147-52. doi: 10.1007/BF00225452.
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Rat embryo nonhistone chromosomal proteins: interaction in vitro with normal and bromodeoxyuridine-substituted DNA.大鼠胚胎非组蛋白染色体蛋白：体外与正常及溴脱氧尿苷取代的DNA的相互作用。
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Expression of human and mouse nonhistone chromosomal proteins in hybrid mouse erythroleukemia cells containing a single human chromosome.在含有一条人类染色体的杂交小鼠红白血病细胞中人类和小鼠非组蛋白染色体蛋白的表达
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Nonhistone chromatin proteins of B-lymphocytes stimulated by lipopolysaccharide. Two-dimensional gel electrophoresis analysis of proteins synthesized and phosphorylated during the initiation of lymphocyte differentiation.脂多糖刺激的B淋巴细胞的非组蛋白染色质蛋白。淋巴细胞分化起始过程中合成和磷酸化的蛋白质的二维凝胶电泳分析。
Biochim Biophys Acta. 1982 Dec 31;699(3):247-54. doi: 10.1016/0167-4781(82)90114-2.
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Fractionation of the phytohemagglutinin of Phaseolus vulgaris by polyacrylamide gel electrophoresis in sodium dodecyl sulphate.用十二烷基硫酸钠聚丙烯酰胺凝胶电泳法对菜豆植物血凝素进行分级分离。
Biochem Biophys Res Commun. 1971 Sep;44(5):1143-8. doi: 10.1016/s0006-291x(71)80205-x.
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Correlation of patterns of nuclear protein synthesis with differentiation of mitogen-stimulated B-lymphocytes.核蛋白合成模式与有丝分裂原刺激的B淋巴细胞分化的相关性。
Immunol Commun. 1983;12(6):605-23. doi: 10.3109/08820138309025441.

本文引用的文献

1
Phosphorylation of nuclear protein early in the course of gene activation in lymphocytes.淋巴细胞基因激活过程早期核蛋白的磷酸化。
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2
On the systhesis of RNA in lymphocytes stimulated by phytohemagglutinin. The activity of deoxyribonucleoprotein-bound and soluble RNA polymerase.关于植物血凝素刺激淋巴细胞中RNA的合成。脱氧核糖核蛋白结合型和可溶性RNA聚合酶的活性。
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Cleavage of structural proteins during the assembly of the head of bacteriophage T4.
在噬菌体T4头部组装过程中结构蛋白的切割
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Effect of protein-bound RNA associated with chick embryo chromatin on template specificity of the chromatin.与鸡胚染色质相关的蛋白质结合RNA对染色质模板特异性的影响。
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Sequence-specific interaction of DNA and chromosomal protein.DNA与染色体蛋白的序列特异性相互作用。
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RNA synthesis and histone acetylation during the course of gene activation in lymphocytes.淋巴细胞基因激活过程中的RNA合成与组蛋白乙酰化。
Proc Natl Acad Sci U S A. 1966 Apr;55(4):805-12. doi: 10.1073/pnas.55.4.805.
7
Synthesis of nuclear-associated proteins by lymphocytes within minutes after contact with phytohemagglutinin.淋巴细胞在与植物血凝素接触后数分钟内合成核相关蛋白。
J Immunol. 1972 Apr;108(4):1105-9.
8
The early stimulation of protein synthesis in sensitized guinea pig lymph node cells by antigen.抗原对致敏豚鼠淋巴结细胞蛋白质合成的早期刺激作用。
J Immunol. 1972 Apr;108(4):1073-9.
9
Molecular weight estimation of polypeptide chains by electrophoresis in SDS-polyacrylamide gels.通过SDS-聚丙烯酰胺凝胶电泳对多肽链进行分子量估计
Biochem Biophys Res Commun. 1967 Sep 7;28(5):815-20. doi: 10.1016/0006-291x(67)90391-9.
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Early nuclear events in the induction of lymphocyte proliferation by mitogens. Effects of concanavalin A on the phosphorylation and distribution of non-histone chromatin proteins.丝裂原诱导淋巴细胞增殖过程中的早期核事件。伴刀豆球蛋白A对非组蛋白染色质蛋白磷酸化和分布的影响。
J Biol Chem. 1974 Aug 10;249(15):4990-9.