Russell C O, Gannan R, Coatsworth J, Neilsen R, Allen F, Hill L D, Pope C E
Dig Dis Sci. 1983 Apr;28(4):289-93. doi: 10.1007/BF01324943.
Esophageal motor function was tested in 12 patients with a clinical diagnosis of diabetic gastroenteropathy by radionuclide transit (RT) studies. Other insulin-dependent diabetics with and without symptoms of peripheral neuropathy but with no symptoms of gastrointestinal disease were similarly studied. Eleven of the 12 patients with gastroenteropathy were found to have abnormal esophageal function, even though only five had esophageal symptoms. Half the diabetics with peripheral neuropathy symptoms, and a quarter of those with no symptoms had abnormal esophageal transit studies. No abnormalities were found in a group of asymptomatic volunteers studied in a similar manner. We conclude that esophageal dysfunction, often subclinical, is present in nearly all patients with suspected diabetic gastroenteropathy. Esophageal dysfunction correlates less well with peripheral neuropathy. This study implies that if a diabetic, presenting with diarrhea or nausea and vomiting, has normal esophageal transit, then a cause for these symptoms, other than diabetic gastroenteropathy, may exist.
通过放射性核素转运（RT）研究，对12例临床诊断为糖尿病性胃肠病的患者进行了食管运动功能测试。对其他有或无周围神经病变症状但无胃肠道疾病症状的胰岛素依赖型糖尿病患者也进行了类似研究。12例胃肠病患者中有11例被发现食管功能异常，尽管只有5例有食管症状。有周围神经病变症状的糖尿病患者中有一半以及无症状的糖尿病患者中有四分之一的食管转运研究结果异常。以类似方式研究的一组无症状志愿者未发现异常。我们得出结论，几乎所有疑似糖尿病性胃肠病的患者都存在食管功能障碍，且通常为亚临床状态。食管功能障碍与周围神经病变的相关性较差。这项研究表明，如果一名出现腹泻或恶心呕吐的糖尿病患者食管转运正常，那么这些症状可能存在糖尿病性胃肠病以外的病因。
