糖尿病自主神经病变中的胃排空
Gastric emptying in diabetic autonomic neuropathy.
作者信息
Campbell I W, Heading R C, Tothill P, Buist T A, Ewing D J, Clarke B F
出版信息
Gut. 1977 Jun;18(6):462-7. doi: 10.1136/gut.18.6.462.
Abstract
Gastric emptying was studied in 12 diabetic patients, six with and six without objective evidence of autonomic neuropathy and in 20 non-diabetic controls, using a double isotope scinti-scanning technique which differentiated between solid and liquid emptying. Three patients with autonomic neuropathy exhibited gastric stasis, although this was detected by conventional radiology in only one. Neither the patients with stasis nor those without exhibited abnormally rapid early gastric emptying. In patients without stasis, the normal differentiation between solid and liquid emptying was impaired, suggesting an abnormality of antral peristalsis not attributable to vagal denervation. Both intravenous and oral metoclopramide produced symptomatic improvement in two patients with gastric stasis and restored their gastric emptying to normal.
摘要
采用双同位素闪烁扫描技术对12例糖尿病患者（6例有自主神经病变客观证据，6例无）及20例非糖尿病对照者的胃排空情况进行了研究，该技术可区分固体和液体排空。3例自主神经病变患者出现胃潴留，尽管传统放射学仅检测到1例。有胃潴留和无胃潴留的患者均未表现出异常快速的早期胃排空。在无胃潴留的患者中，固体和液体排空的正常差异受损，提示胃窦蠕动异常并非由迷走神经去神经支配所致。静脉注射和口服甲氧氯普胺均使2例胃潴留患者症状改善，并使胃排空恢复正常。
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