Prechel M M, Audhya T K, Schlesinger D H
Endocrinology. 1983 Apr;112(4):1474-8. doi: 10.1210/endo-112-4-1474.
Groups of male and female laboratory rats, 28-30 days of age, were killed each week from July 1980 to September 1981. Pineal glands were collected, pooled, and extracted. Arginine vasotocin (AVT) activity in the extracts was measured by RIA. For most of the calendar year, pineal AVT immunoactivity ranged between 1.8-7.7 pg/gland. The average (+/- SE) basal AVT activity level was 4.1 +/- 0.3 pg/gland (n = 48). Both years in early August, pineal AVT activity increased several hundred fold. Values of 1720 and 1170 pg/gland were measured in mid-August of 2 successive years. The signal for this dramatic yearly rhythm, and its physiological consequences, are as yet unknown.
1980年7月至1981年9月期间，每周处死一组28 - 30日龄的雄性和雌性实验大鼠。收集松果体，集中起来并进行提取。提取物中的精氨酸血管加压素（AVT）活性通过放射免疫分析进行测定。在一年中的大部分时间里，松果体AVT免疫活性在1.8 - 7.7 pg/腺体之间。基础AVT活性水平的平均值（±标准误）为4.1±0.3 pg/腺体（n = 48）。在这两年的8月初，松果体AVT活性增加了数百倍。连续两年8月中旬测得的值分别为1720和1170 pg/腺体。这种显著的年度节律信号及其生理后果目前尚不清楚。
