Dickenson A H, Le Bars D
Exp Brain Res. 1983;49(2):174-80. doi: 10.1007/BF00238577.
Fifty-eight lumbar dorsal horn and trigeminal nucleus caudalis neurones which could be activated by both innocuous and noxious peripheral stimuli have been recorded in the anaesthetized rat. Using transcutaneous electrical stimulation to produce A and C fibre activity in these neurones from the hindpaw or facial receptive fields the ability of a distant noxious (mechanical or thermal) stimulus applied to the nose, tail, ears and paws to inhibit the neuronal activity was demonstrated. These effects have been termed diffuse noxious inhibitory controls (DNIC). DNIC produced powerful long-lasting inhibitions on all units studied in accordance with our previous results. Approximately 40% of these convergent neurones could be antidromically activated from the contralateral ventrobasal thalamus. Similar neuronal characteristics, effects of DNIC and proportions of projection cells were found in both the dorsal horn and trigeminal complex. However, the spinothalamic tract cells conducted more rapidly than the trigeminothalamic neurones. These results indicate that DNIC can produce comparable effects on the thalamic representation of the efferent activity of these spinal cord and trigeminal neurones. The possible role of DNIC in nociception is discussed.
在麻醉大鼠中记录到58个腰段背角和三叉神经尾侧核神经元，这些神经元可被无害和有害的外周刺激激活。利用经皮电刺激在这些神经元中产生来自后爪或面部感受野的A和C纤维活动，证明了施加于鼻子、尾巴、耳朵和爪子的远距离有害（机械或热）刺激抑制神经元活动的能力。这些效应被称为弥漫性有害抑制控制（DNIC）。根据我们之前的结果，DNIC对所有研究的单位产生了强大而持久的抑制作用。这些会聚神经元中约40%可从对侧腹基底丘脑被逆向激活。在背角和三叉复合体中发现了相似的神经元特征、DNIC效应和投射细胞比例。然而，脊髓丘脑束细胞的传导速度比三叉丘脑神经元更快。这些结果表明，DNIC可对这些脊髓和三叉神经元传出活动的丘脑表征产生类似的影响。文中讨论了DNIC在伤害感受中的可能作用。
