抗组胺药二甲茚定对哺乳动物心肌跨膜电位的影响。
Effect of dimethindene, an antihistaminic drug, on the transmembrane potentials of mammalian myocardium.
作者信息
Mészáros J, Hlavacsek-Póka E, Szegi J
出版信息
Experientia. 1983 Apr 15;39(4):400-2. doi: 10.1007/BF01963146.
PMID:6832322
Abstract
Dimethindene (DMI) decreased the maximum rate of rise of action potential (AP) without changing the resting potential in cat ventricular myocardium. DMI abolished the histamine-induced slow APs in left atria but not in right ventricular papillary muscles of guinea-pig, suggesting that DMI blocked the histamine H1-receptors.
摘要
二甲茚定（DMI）降低了猫心室肌动作电位（AP）的最大上升速率，而不改变静息电位。DMI消除了组胺诱导的豚鼠左心房慢动作电位，但在右心室乳头肌中未消除，这表明DMI阻断了组胺H1受体。
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