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抗组胺药二甲茚定对哺乳动物心肌跨膜电位的影响。

Effect of dimethindene, an antihistaminic drug, on the transmembrane potentials of mammalian myocardium.

作者信息

Mészáros J, Hlavacsek-Póka E, Szegi J

出版信息

Experientia. 1983 Apr 15;39(4):400-2. doi: 10.1007/BF01963146.

DOI:10.1007/BF01963146
PMID:6832322
Abstract

Dimethindene (DMI) decreased the maximum rate of rise of action potential (AP) without changing the resting potential in cat ventricular myocardium. DMI abolished the histamine-induced slow APs in left atria but not in right ventricular papillary muscles of guinea-pig, suggesting that DMI blocked the histamine H1-receptors.

摘要

二甲茚定（DMI）降低了猫心室肌动作电位（AP）的最大上升速率，而不改变静息电位。DMI消除了组胺诱导的豚鼠左心房慢动作电位，但在右心室乳头肌中未消除，这表明DMI阻断了组胺H1受体。

相似文献

1
Effect of dimethindene, an antihistaminic drug, on the transmembrane potentials of mammalian myocardium.抗组胺药二甲茚定对哺乳动物心肌跨膜电位的影响。
Experientia. 1983 Apr 15;39(4):400-2. doi: 10.1007/BF01963146.
2
Action of dimethindene on the electrophysiological and mechanical properties of atrial and ventricular myocardium of guinea-pig.
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引用本文的文献

1
Blockage of the fast sodium current by dimethindene in frog auricular fibres.二甲茚定对蛙心耳纤维快钠电流的阻断作用。
Naunyn Schmiedebergs Arch Pharmacol. 1987 Mar;335(3):321-5. doi: 10.1007/BF00172804.
2
Electrophysiological characterization of histamine receptor subtypes in mammalian heart preparations.哺乳动物心脏制剂中组胺受体亚型的电生理特性
Naunyn Schmiedebergs Arch Pharmacol. 1986 Nov;334(3):294-302. doi: 10.1007/BF00508785.
3
Electrophysiological actions of histamine and H1-, H2-receptor antagonists in cardiac tissue.

本文引用的文献

1
A pharmacologic investigation of dimethpyrindene maleate (Forhistal).
Toxicol Appl Pharmacol. 1961 Sep;3:534-44. doi: 10.1016/0041-008x(61)90044-8.
2
Effect of dantrolene sodium on the transmembrane potentials and contractility of guinea pig atrial myocardium.丹曲林钠对豚鼠心房肌跨膜电位及收缩性的影响。
Eur J Pharmacol. 1981 Sep 11;74(2-3):181-8. doi: 10.1016/0014-2999(81)90529-x.
3
Activity index of frog heart ventricle cells. Analysis of the correlation between resting potential and activity of the sodium-carrier system in the frog heart by means of celluline and adrenaline.蛙心心室细胞的活动指数。通过纤维素和肾上腺素分析蛙心静息电位与钠载体系统活性之间的相关性。
组胺及H1、H2受体拮抗剂在心脏组织中的电生理作用。
Agents Actions. 1986 Apr;18(1-2):186-90. doi: 10.1007/BF01988017.
Acta Physiol Acad Sci Hung. 1968;33(3):269-84.
4
Calcium-dependent action potentials produced by catecholamines in guinea pig atrial muscle fibers depolarized by potassium.儿茶酚胺在经钾离子去极化的豚鼠心房肌纤维中产生的钙依赖性动作电位
Circ Res. 1970 Sep;27(3):379-90. doi: 10.1161/01.res.27.3.379.
5
Mechanism of the histamine-induced positive inotropic action in cardiac muscle.组胺诱导心肌正性肌力作用的机制。
Eur J Pharmacol. 1976 Feb;35(2):393-8. doi: 10.1016/0014-2999(76)90243-0.
6
Influence of H1- and H2-receptor antagonists on the circulatory system and on the endogenous plasma histamine concentrations in dogs.H1和H2受体拮抗剂对犬循环系统及内源性血浆组胺浓度的影响。
Agents Actions. 1977 Mar;7(1):97-101. doi: 10.1007/BF01964888.
7
Classification of antidysrhythmic drugs.抗心律失常药物的分类。
Pharmacol Ther B. 1975;1(1):115-38. doi: 10.1016/0306-039x(75)90019-7.
8
Ionic mechanisms in heart muscle in relation to the genesis and the pharmacological control of cardiac arrhythmias.心肌中的离子机制与心律失常的发生及药物控制
Pharmacol Rev. 1978 Mar;30(1):5-63.
9
Time- and voltage-dependent interactions of antiarrhythmic drugs with cardiac sodium channels.
Biochim Biophys Acta. 1977 Nov 14;472(3-4):373-98. doi: 10.1016/0304-4157(77)90003-x.
10
Slow Ca2+ and Na+ responses induced by isoproterenol and methylxanthines in isolated perfused guinea pig hearts exposed to elevated K+.
J Mol Cell Cardiol. 1975 Apr;7(4):249-73. doi: 10.1016/0022-2828(75)90084-x.