Humphreys F, Shuster S
Br J Clin Pharmacol. 1987 Feb;23(2):234-6. doi: 10.1111/j.1365-2125.1987.tb03035.x.
The topical effect of the histamine H1-receptor antagonist dimethindene maleate on the wealing response to intradermal histamine, compound 48/80 and house dust mite antigen was studied in 16 subjects using a double-blind procedure. The mean reduction in weal area +/- s.e. mean was 44% +/- 13%, 43% +/- 13% and 31% +/- 13% for histamine, 48/80 and antigen respectively. We conclude that dimethindene maleate is a moderately potent H1-receptor antagonist, and that the inhibition of the 48/80 and house dust mite induced weals is accounted for by the antihistaminic effect of dimethindene maleate.
采用双盲法对16名受试者研究了组胺H1受体拮抗剂马来酸氯苯那敏对皮内注射组胺、48/80化合物和屋尘螨抗原所致风团反应的局部作用。组胺、48/80化合物和抗原所致风团面积平均减少率±标准误分别为44%±13%、43%±13%和31%±13%。我们得出结论，马来酸氯苯那敏是一种中等强度的H1受体拮抗剂，其对48/80化合物和屋尘螨诱导的风团的抑制作用是由马来酸氯苯那敏的抗组胺作用所致。
