小鼠成纤维细胞中期染色体中的DNA结构。
Structure of DNA in metaphase chromosomes of mouse fibroblasts.
作者信息
Belyaev N D, Budker V G, Dubrovskaya V A, Matveeva N M
出版信息
FEBS Lett. 1983 Apr 18;154(2):285-7. doi: 10.1016/0014-5793(83)80167-7.
PMID:6832370
Abstract
We show that N-1 in adenine of chromosomal DNA is methylated by treatment of metaphase chromosomes with dimethylsulphate while this is not the case in chromatin. The data on methylation are consistent with those obtained from the experiments with S1-nuclease treatment of chromatin and chromosomes. This suggests a disarrangement of DNA secondary structure in the metaphase chromosomes.
摘要
我们发现，用硫酸二甲酯处理中期染色体时，染色体DNA腺嘌呤中的N-1会发生甲基化，而在染色质中则不会。甲基化数据与用S1核酸酶处理染色质和染色体的实验结果一致。这表明中期染色体中DNA二级结构发生了紊乱。
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