Malè P J, de Toledo F, Widgren S, de Peyer R, Berthoud S
Gut. 1983 Apr;24(4):345-50. doi: 10.1136/gut.24.4.345.
We report a seven year history of a 23 year old woman born in the Antilles, with pseudotumoral enterocolitis and massive eosinophilia. In 1973 she developed a haemorrhagic colitis with massive peripheral eosinophilia of up to 60000/mm3. Medical treatment, mainly corticosteroids, failed to control the disease. The patient temporarily improved after colectomy and remained in remission for two years. In 1978 the disease recurred in the rectum and small intestine with formation of tumour-like granulomata and massive infiltration by eosinophils, unresponsive to corticosteroids. Intestinal blood and protein loss continued until death seven years after onset. In spite of exhaustive investigation, no parasites, allergens, or other aetiological agents could be found. As only the gut was infiltrated, the hypereosinophilic syndrome could be excluded. The enterocolitis here described does not correspond to an eosinophilic gastroenteritis, nor to other known inflammatory bowel diseases and to our knowledge has not been reported previously.
我们报告了一名23岁出生于安的列斯群岛的女性，患有假瘤性小肠结肠炎和大量嗜酸性粒细胞增多症，病程长达七年。1973年，她患上了出血性结肠炎，外周血嗜酸性粒细胞大量增多，高达60000/mm³。主要使用皮质类固醇的药物治疗未能控制病情。患者在结肠切除术后暂时好转，并维持缓解状态两年。1978年，疾病在直肠和小肠复发，形成肿瘤样肉芽肿，并有大量嗜酸性粒细胞浸润，对皮质类固醇无反应。肠道血液和蛋白质流失持续存在，直至发病七年后死亡。尽管进行了详尽的检查，未发现寄生虫、过敏原或其他病因。由于仅肠道受到浸润，可排除高嗜酸性粒细胞综合征。这里描述的小肠结肠炎既不符合嗜酸性粒细胞性胃肠炎，也不符合其他已知的炎症性肠病，据我们所知，此前未曾有过相关报道。
