Perrot P A, Berthoud S, Widgren S
Schweiz Med Wochenschr. 1979 Jun 16;109(24):920-7.
A 23-year-old woman from the French Antilles was successfully treated for intestinal and hepatic schistosomiasis, as evidenced by the normalization of immunofluorescence titers and many negative histogogical controls. She presented, however, persistent colitis with marked eosinophilia (eosinophils in excess of 50,000/mm3). No precise diagnosis could be established in spite of all parasitological, allergological, hematological and gastroenterological investigations. The colon was the only organ involved and showed colitis of a type unclassifiable both endoscopically and histologically. Massive infiltration by eosinophils was present. Temporary relief was achieved with steroids but the clinical condition of the patient became dramatic. Three years after the onset of the illness total colectomy was performed, sparing the rectum. After surgery all manifestations of disease disappeared and for ten months the number of eosinophils was normal. Ileorectal continuity could be re-established. Ten months after reanastomosis there was recurrence of bleeding from the rectum and eosiophils once again reached levels of 2340/mm3. The differential diagnosis of this colitis associated with eosinophilia is discussed. To our knowledge it does not correspond to any clinical entity described so far.
一名来自法属安的列斯群岛的23岁女性成功治愈了肠道和肝脏血吸虫病，免疫荧光滴度恢复正常以及多次组织学检查结果为阴性均证明了这一点。然而，她仍患有持续性结肠炎，伴有明显的嗜酸性粒细胞增多（嗜酸性粒细胞超过50,000/mm³）。尽管进行了所有寄生虫学、变应性学、血液学和胃肠病学检查，仍无法明确诊断。结肠是唯一受累的器官，其结肠炎在内镜检查和组织学检查中均无法分类。存在大量嗜酸性粒细胞浸润。使用类固醇药物后病情暂时缓解，但患者的临床状况仍很严重。发病三年后，进行了全结肠切除术，保留了直肠。手术后，所有疾病表现均消失，嗜酸性粒细胞数量在十个月内恢复正常。回肠直肠连续性得以重建。重新吻合术后十个月，直肠再次出血，嗜酸性粒细胞数量再次达到2340/mm³。本文讨论了这种与嗜酸性粒细胞增多相关的结肠炎的鉴别诊断。据我们所知，它不符合迄今为止所描述的任何临床实体。
