Ford J H, Callen D F, Roberts C G, Jahnke A B
Hum Genet. 1983;63(1):58-62. doi: 10.1007/BF00285399.
The size of the heterochromatic regions of chromosomes 1 and 16 was measured in a Test group of women with histories of recurrent spontaneous abortion and a Control group of fertile women. Measurements were made on Giemsa banded preparations and the euchromatic regions of 1q and 16q were used to correct for between-cell contraction. For each chromosome pair, the larger and smaller chromosome was identified and populations of each were compared between the two subject groups. For chromosome 1, the smaller chromosome of the Test group was significantly smaller than that of the Control group (P less than 0.001) and the size of the pair difference was larger in the Test than in the Control group (P less than 0.01). For chromosome 16, the smaller chromosome of the Test group was smaller than that of the Control group (5% level). The interaction of chromosome 1 and chromosome 9 heterochromatin in each individual has been analyzed. The combined score for the smaller chromosome 1 and the larger chromosome 9 shows a bimodal distribution and allows discrimination between the two subject groups. Various possible ways in which this interaction might affect reproductive outcome are discussed.
在一组有反复自然流产史的女性试验组和一组可育女性对照组中，测量了1号和16号染色体异染色质区域的大小。测量在吉姆萨染色带标本上进行，1q和16q的常染色质区域用于校正细胞间收缩。对于每对染色体，确定较大和较小的染色体，并比较两个受试组中每组的数量。对于1号染色体，试验组中较小的染色体明显小于对照组（P小于0.001），试验组中染色体对差异的大小大于对照组（P小于0.01）。对于16号染色体，试验组中较小的染色体小于对照组（5%水平）。分析了每个个体中1号染色体和9号染色体异染色质的相互作用。较小的1号染色体和较大的9号染色体的综合评分显示出双峰分布，并且能够区分两个受试组。讨论了这种相互作用可能影响生殖结果的各种可能方式。
