Lerman M I, Abakumova O Y, Kucenko N G, Kobrina E M, Schechter A B, Mamedov L A, Nikolaev A V
Lancet. 1977 Jun 11;1(8024):1225-8. doi: 10.1016/s0140-6736(77)92436-9.
The effect of low-molecular-weight cell constituents from regenerating liver and granulation tissue on the growth of the connective tissue during skin wound healing has been investigated. Repeated injections (intravenous or subcutaneous) of these compounds greatly accelerated the growth of connective tissue by stimulation of both fibroblast proliferation and collagen biogenesis and thus promoted wound healing. These results suggest that the low-molecular-weight cell constituents from dividing cells contain internal factor(s) capable of committing resting cells to D.N.A. synthesis and division or of accelerating D.N.A. synthesis in committed cells.
研究了来自再生肝和肉芽组织的低分子量细胞成分对皮肤伤口愈合过程中结缔组织生长的影响。重复注射（静脉内或皮下）这些化合物，通过刺激成纤维细胞增殖和胶原蛋白生物合成，极大地加速了结缔组织的生长，从而促进了伤口愈合。这些结果表明，来自分裂细胞的低分子量细胞成分含有能够使静止细胞进行DNA合成和分裂或加速已分化细胞中DNA合成的内部因子。
