[DNA synthesis by granulation tissue fibroblasts under conditions of stimulation of the wound process].

The changes in the DNA synthesis in the granulation tissue fibroblasts in the wounds of adult animals given potassium orotate and in controls were studied. For this purpose a daily autoradiographic examination of the wound areas were conducted in the both groups of animals. It appeared that under the effect of potassium orotate (0.2 ml of 2% solution) there was more frequent involvement of fibroblasts into the DNA synthesis; under conditions of the wound process stimulation there occurred an increase of the proliferative activity of these cells.