Walrath J, Fraumeni J F
Int J Cancer. 1983 Apr 15;31(4):407-11. doi: 10.1002/ijc.2910310403.
In view of recent findings of nasal cancer in rats exposed to formaldehyde vapors, we investigated the proportionate mortality experience of embalmers licensed to practice in New York State. Mortality was significantly elevated for cancers of the skin and colon and for arteriosclerotic heart disease, whereas significant deficits were seen in mortality from respiratory diseases and accidents. Respiratory cancer mortality was not excessive and no deaths were attributed to nasal cancer. Mortality was significantly elevated for cancers of the skin, kidney, and brain among those licensed only as embalmers, whereas mortality patterns were unremarkable among those licensed also as funeral directors (and presumably less exposed to formaldehyde) These preliminary results indicate the need for occupational cohort studies to clarify the carcinogenic potential of formaldehyde.
鉴于近期在接触甲醛蒸汽的大鼠身上发现了鼻癌,我们调查了在纽约州获得执业许可的防腐师的比例死亡率情况。皮肤癌、结肠癌以及动脉硬化性心脏病的死亡率显著升高,而呼吸系统疾病和事故导致的死亡率则显著降低。呼吸道癌死亡率并未过高,且没有死亡病例归因于鼻癌。仅获得防腐师执照的人员中,皮肤癌、肾癌和脑癌的死亡率显著升高,而那些同时还获得葬礼主管执照(推测接触甲醛较少)的人员的死亡率模式并无异常。这些初步结果表明需要开展职业队列研究以阐明甲醛的致癌潜力。