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甲醛暴露与白血病和其他淋巴血液系统恶性肿瘤风险的流行病学证据的批判性回顾与综合。

Critical review and synthesis of the epidemiologic evidence on formaldehyde exposure and risk of leukemia and other lymphohematopoietic malignancies.

机构信息

Department of Environmental Health, School of Public Health and Medicine, University of Washington, Box 357234, Seattle, WA 98195, USA.

出版信息

Cancer Causes Control. 2012 Nov;23(11):1747-66. doi: 10.1007/s10552-012-0055-2. Epub 2012 Sep 15.

DOI:10.1007/s10552-012-0055-2
PMID:22983399
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3465649/
Abstract

PURPOSE

Recent epidemiologic studies indicate elevated risks for some lymphohematopoietic malignancies (LHM) related to formaldehyde exposure. We performed a systematic review of literature to assess the strength and consistency of associations.

METHODS

We summarized published literature in the PubMed database of the National Library of Medicine during 1966-2012. Literature was categorized according to study design and population: industrial cohort studies, professional cohort studies, and population-based case-control studies.

RESULTS

Findings from occupational cohort and population-based case-control studies were very inconsistent for LHM, including myeloid leukemia. Apart from some isolated exceptions, relative risks were close to the null, and there was little evidence for dose-response relations for any of the LHM.

CONCLUSIONS

At present, there is no consistent or strong epidemiologic evidence that formaldehyde is causally related to any of the LHM. The absence of established toxicological mechanisms further weakens any arguments for causation. To be informative, future epidemiologic research should improve on formaldehyde exposure assessment and apply modern diagnostic schemes for specific LHM.

摘要

目的

最近的流行病学研究表明，甲醛暴露与某些淋巴血液系统恶性肿瘤（LHM）的风险升高有关。我们进行了系统的文献综述，以评估关联的强度和一致性。

方法

我们总结了国家医学图书馆 PubMed 数据库中 1966 年至 2012 年期间发表的文献。文献根据研究设计和人群进行分类：工业队列研究、专业队列研究和基于人群的病例对照研究。

结果

职业队列和基于人群的病例对照研究对于 LHM（包括髓性白血病）的结果非常不一致。除了一些孤立的例外，相对风险接近零，并且对于任何 LHM 都没有证据表明存在剂量反应关系。

结论

目前，没有一致或强有力的流行病学证据表明甲醛与任何 LHM 有因果关系。缺乏既定的毒理学机制进一步削弱了任何因果关系的论点。为了提供信息，未来的流行病学研究应改进甲醛暴露评估，并应用特定 LHM 的现代诊断方案。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/348c/3465649/d5d7b0f6f3f2/10552_2012_55_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/348c/3465649/f0e165a0b5f9/10552_2012_55_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/348c/3465649/32cc274c3c8b/10552_2012_55_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/348c/3465649/b145eaf3e424/10552_2012_55_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/348c/3465649/c70a25c45739/10552_2012_55_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/348c/3465649/d5d7b0f6f3f2/10552_2012_55_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/348c/3465649/f0e165a0b5f9/10552_2012_55_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/348c/3465649/32cc274c3c8b/10552_2012_55_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/348c/3465649/b145eaf3e424/10552_2012_55_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/348c/3465649/c70a25c45739/10552_2012_55_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/348c/3465649/d5d7b0f6f3f2/10552_2012_55_Fig5_HTML.jpg

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