Smith L R, Brantley D D, Swain K A, Demis D A
Health Phys. 1983 Mar;44(3):221-34. doi: 10.1097/00004032-198303000-00002.
Graphs of excretion patterns following occupational uptake of 3H, 14C and 35S labeled compounds in humans are presented. A brief description of New England Nuclear's bioassay program and analytical methods is given. One or two exponential regression curves are found to fit most sets of data. Exceptions where exponentials do not closely fit the data are discussed. Characteristic rate constants are estimated and used to establish retention equations. When groups of workers were exposed to the same source excretion parameters were not found to strongly correlate with weight or sex. Variations in individual excretion patterns following low level group exposure did not significantly effect individual dose commitment estimates. Excretion rates following uptake of 14C and 3H labeled compounds were found to span three orders of magnitude. This indicates that health physicists may tend to dissipate resources in unnecessary investigations if conservative ICRP recommendations are assumed.
文中呈现了人类职业性摄入3H、14C和35S标记化合物后的排泄模式图表。对新英格兰核公司的生物测定计划和分析方法进行了简要描述。发现一两条指数回归曲线能拟合大多数数据集。讨论了指数曲线与数据拟合不紧密的例外情况。估算了特征速率常数并用于建立滞留方程。当一组工人暴露于同一源时，未发现排泄参数与体重或性别有很强的相关性。低水平群体暴露后个体排泄模式的变化对个体剂量承诺估计没有显著影响。发现摄入14C和3H标记化合物后的排泄率跨越三个数量级。这表明，如果假定采用国际放射防护委员会（ICRP）的保守建议，健康物理学家可能会在不必要的调查中浪费资源。
