Shaw C F, Chiang S T, Hsieh Y C, Milic-Emili J, Lenfant C
J Appl Physiol Respir Environ Exerc Physiol. 1983 Feb;54(2):594-7. doi: 10.1152/jappl.1983.54.2.594.
A new method for measuring the resistance of the total respiratory system is presented. The method uses a device comprising a solenoid valve, a multiperforated plate, and a pneumotachograph. The multiperforated plate serves as a constant resistor (Rk) that is used to partially occlude the airway opening, thus rapidly and briefly reducing airflow during natural expiration. If it is assumed that the driving pressure remains constant during the very short period the airway is partially occluded, the respiratory flow immediately preceding the addition of Rk (V) and the flow reduction during partial occlusion (delta V) allow calculation of the resistance of the total respiratory system. The resistance of 14 normal subjects and 18 patients with chronic obstructive pulmonary disease (COPD) was measured with this new method as well as with the body plethysmographic method: 90% of the interrupter values fell within +/- 0.6 cmH2O . l-1.s of the plethysmographic values, and all fell within +/- 0.8 cmH2O . l-1.s.
本文提出了一种测量全呼吸系统阻力的新方法。该方法使用一种装置，该装置包括一个电磁阀、一个多孔板和一个呼吸流速计。多孔板用作恒定电阻器（Rk），用于部分阻塞气道开口，从而在自然呼气过程中快速短暂地减少气流。如果假设在气道部分阻塞的非常短的时间段内驱动压力保持恒定，那么在添加Rk之前的呼吸流量（V）和部分阻塞期间的流量减少（ΔV）就可以计算出全呼吸系统的阻力。用这种新方法以及体容积描记法测量了14名正常受试者和18名慢性阻塞性肺疾病（COPD）患者的阻力：90%的阻断器值落在体容积描记法值的±0.6 cmH2O·l-1·s范围内，所有值均落在±0.8 cmH2O·l-1·s范围内。
